Having bested The Admin's icy obstacles, Jesse and the gang are rewarded with a one-way trip to The Sunshine Institute, a nigh, inescapable prison buried at the bottom of the world and filled with all manner of miscreants. In order to make it back home, Jesse has to find a way to break out, even if that means employing a few desperate measures...
Jesse and the gang must brave a dangerous prison and its even more dangerous inmates to reach the secret at the prison's heart... But when the enemy tries to recruit Jesse's friends, will they be able to resist the call?
- Patton Oswalt as Jesse (Male) and Romeo (Jesse Form)
- Catherine Anne "Cat" Taber as Jesse (Female) and Romeo (Jesse Form)
- Yuri Lowenthal as Radar
- Ashley Johnson as Petra
- Fred Tatasciore as Jack and Brick
- Mark Barbolak as Nurm and Rob
- April Stewart as Xara
- Donovan Patton as The Warden
- Ashley Albert as Stella
- Jean-Benoît "J.B." Blanc as Romeo
- Gregg Berger as Oxblood
- "Bigbst4tz2" as Anthony
- Shane Snider as Terry and Carmine
- Giant Ghast (No Lines)
- Geoff (No Lines)
- Large Henry (No Lines)
- Lluna (No Lines)
- Big Hank (No Lines)
- Giant Enderman (No Lines)
- Ivor (Epilogue, No Lines)
- The Warden
- Giant Ghast
- Fred (Confirmed Death)
- Hostile Mobs
Radar was being tortured as leverage... Did you agree to work for the Warden?
- 56.6% of players agreed to work for the Warden.
- 43.4% refused to work for the Warden.
Geoff the Mooshroom was not allowed to stay... Did you shear him?
- 55.8% of players refused the Warden's order.
- 44.2% of players sheared Geoff.
You had to convince Stella to help you... How did she respond to your request?
- 73.7% of players has Stella on the inside of Romeo's circle of trust.
- 26.3% of players didn't have Stella on the inside of Romeo's circle of trust.
Xara left you in her booby-trapped cell... Who did you leave behind?
- 53.8% of players left Lluna behind.
- 46.2% of players left Nurm behind.
Xara ran ahead during the escape... Did you stick together?
- 87.2% of players stayed behind to help Xara.
- 12.8% of players left Xara to fight the monsters herself.
- The title is a pun of Elvis Presley's song, Jailhouse Rock.
- Chris Reiser and Adam Douglas were confirmed to be the lead writer and directer for "Jailhouse Block". 
- It was confirmed that "Jailhouse Block" was getting more language dubs.
- It was confirmed on The IGN Show and by Eric Stirpe that "Jailhouse Block" would release on September 19th, 2017. 
- Although being in "Giant Consequences", Lukas' voice actor, Scott Porter, could not be in "Jailhouse Block", as of him becoming a father and not having enough time to record his dialogue.