- "After so long being the Founder and the Eversource, now we can just be 'Isa' and her best friend... Benedict."
- —Isa to Jesse's Gang. src
Isa appears to be a mature, dominant woman with black hair who wears a long golden gown and a golden crown. She is the strict ruler of Sky City and is responsible of her citizens and what they craft, build, and smelt.
Isa is portrayed to be a dominant and controlling character who likes to be in charge. At first, she seems negative, however, as the story progresses, she becomes supportive of Jesse and his/her gang. She is also a great martial artist, duelist and builder. Jesse can even choose to say to Milo that Isa's heart is in the right place.
- Numerous Hostile Mobs
- Iron Sword (x2)
- Stone Sword (x2) (Formerly)
- Cobblestone (Formerly)
- Dirt (Formerly)
- Eversource Crown (Formerly)
- "And when something falls... it is gone forever."
- —Isa to Jesse in Sky City. (Determinant) src
- —Isa, (sarcastically) to Jesse, after being called a control freak. (Determinant) src
- "I can't decide whether I want our death to be painless for my sake, or excruciating for yours!"
- —Isa to Jesse. src
- "This has been down here the whole time..."
- —Isa discovering ground below Sky City. src
- "I guess the era of Sky City is over..."
- —Isa. src
- "People of Sky City, a crime has been committed."
- —Isa to citizens of Sky City. src
- "I believe so, and when I get up there I'm gonna tear those Blaze Rods limb from limb."
- —Isa to Jesse, about to head back up to Sky City. src
- She has a similar appearance to the Caucasian female Jesse.
- Isa is the first character in Minecraft: Story Mode that dual wields swords.
- Her voice actor, Melissa Hutchison, also voiced Clementine in The Walking Dead Seasons 1, 2, and 3, and T.J. and Beauty in The Wolf Among Us Season 1.
- Reginald explains that Isa is solely responsible for the construction of Sky City.